| WTA Madrid | 04/22 08:00 | 14 | [69] Greet Minnen v Darja Semenistaja [113] | 3-6,6-2,6-4 | |
| ITF W75 Chiasso | 04/18 11:40 | 26 | [205] Lois Boisson v Darja Semenistaja [113] | 7-5,6-1 | |
| ITF W75 Chiasso | 04/17 14:55 | 25 | [393] Marina Melnikova v Darja Semenistaja [113] | 2-6,5-7 | |
| Billie Jean King Cup | 04/13 12:00 | 2 | [87] Clara Tauson v Darja Semenistaja [110] | Retired | |
| Billie Jean King Cup | 04/11 11:30 | 2 | [110] Darja Semenistaja v Maria Sakkari [6] | 0-6,5-7 | |
| Billie Jean King Cup | 04/10 10:00 | 1 | [110] Darja Semenistaja v Ipek Oz [196] | 2-6,4-6 | |
| Billie Jean King Cup | 04/09 09:55 | 1 | [110] Darja Semenistaja v Eva Vedder [413] | 6-2,3-6,6-3 | |
| Billie Jean King Cup | 04/08 10:00 | 1 | Darja Semenistaja v Angelina Voloshchuk | 4-6,6-1,6-1 | |
| WTA La Bisbal D'Emporda | 04/02 14:25 | 25 | [128] Olga Danilovic v Darja Semenistaja [106] | 6-3,6-1 | |
| WTA Adalia | 03/28 10:15 | 26 | [151] Moyuka Uchijima v Darja Semenistaja [109] | 7-6,6-0 | |
| WTA Adalia | 03/27 08:00 | 25 | [195] Carole Monnet v Darja Semenistaja [109] | 0-6,3-6 | |
| WTA Miami | 03/18 16:30 | 15 | [87] Laura Siegemund v Darja Semenistaja [110] | 6-0,6-2 | |
| WTA Miami | 03/17 16:35 | 14 | [110] Darja Semenistaja v Arina Rodionova [104] | 7-6,6-2 | |
| WTA Charleston | 03/10 18:55 | 14 | [110] Darja Semenistaja v McCartney Kessler [123] | 3-6,1-6 | |
| WTA Charleston | 03/10 17:30 | 14 | Darja Semenistaja v Renata Zarazua | Cancelled | |
| WTA Indian Wells | 03/05 00:20 | 14 | [90] Harriet Dart v Darja Semenistaja [110] | 6-2,6-2 | |
| WTA Austin | 02/29 18:30 | 26 | [115] Darja Semenistaja v Xiyu Wang [64] | 1-6,2-6 | |
| WTA Austin | 02/27 17:00 | 25 | [115] Darja Semenistaja v Victoria Jimenez Kasintseva [318] | 6-7,6-2,6-4 | |
| WTA Mumbai | 02/11 13:45 | 29 | [121] Darja Semenistaja v Storm Hunter [150] | 5-7,7-6,6-2 | |
| WTA Mumbai | 02/10 11:00 | 28 | [121] Darja Semenistaja v Arianne Hartono [153] | 7-5,6-4 | |
| WTA Mumbai | 02/09 13:00 | 27 | [162] Polina Kudermetova v Darja Semenistaja [121] | 4-6,3-6 | |
| WTA Mumbai | 02/07 07:40 | 26 | [305] Amandine Hesse v Darja Semenistaja [121] | 6-2,4-6,4-6 | |
| WTA Mumbai | 02/05 05:30 | 25 | [159] Panna Udvardy v Darja Semenistaja [121] | 5-7,6-3,2-6 | |
| ITF W50 Indore | 02/01 04:30 | 26 | [120] Darja Semenistaja v Saki Imamura [473] | 3-6,4-6 | |
| ITF W50 Indore | 01/31 04:30 | 25 | Darja Semenistaja v Vaishnavi Adkar | 6-2,6-0 | |
| ITF W50 Pune | 01/27 05:30 | 28 | [142] Darja Semenistaja v Moyuka Uchijima [171] | 4-6,6-2,6-7 | |
| ITF W50 Pune | 01/26 04:30 | 27 | [142] Darja Semenistaja v Alexandra Eala [187] | 7-6,6-0 | |
| ITF W50 Pune | 01/25 04:30 | 26 | [142] Darja Semenistaja v Naho Sato [441] | 6-1,6-7,6-2 | |
| ITF W50 Pune | 01/24 06:45 | 25 | [142] Darja Semenistaja v Sahaja Yamalapalli [336] | 5-7,6-3,6-3 | |
| ITF W50 Bengaluru | 01/21 11:30 | 29 | [142] Darja Semenistaja v Carole Monnet [189] | Retired |