| Wimbledon | 06/22 10:00 | 19 | [120] Zdenek Kolar v Mario Vilella Martinez [261] | Retired | |
| Wimbledon | 06/20 13:20 | 14 | [261] Mario Vilella Martinez v Altug Celikbilek [181] | 6-2,7-6 | |
| Open di Francia | 05/16 08:00 | 14 | [224] Mario Vilella Martinez v Aleksandar Vukic [123] | 5-7,4-6 | |
| Challenger Murcia | 04/04 12:30 | 25 | Alexander Shevchenko v Mario Vilella Martinez | Cancelled | |
| Challenger Marbella | 03/28 10:35 | 25 | [172] Mario Vilella Martinez v Yannick Hanfmann [109] | 3-6,0-6 | |
| ATP Buenos Aires | 02/05 19:10 | 14 | [169] Mario Vilella Martinez v Yannick Hanfmann [120] | 6-4,6-7,3-6 | |
| Australian Open | 01/11 23:00 | 15 | [175] Mario Vilella Martinez v Elias Ymer [169] | 6-4,4-6,6-7 | |
| Australian Open | 01/10 03:15 | 14 | [177] Mario Vilella Martinez v Dudi Sela [381] | 6-3,6-2 | |
| Challenger Alicante | 10/14 11:45 | 26 | [273] Nuno Borges v Mario Vilella Martinez [173] | 3-6,6-3,6-1 | |
| Challenger Alicante | 10/12 11:40 | 25 | [452] Georgii Kravchenko v Mario Vilella Martinez [173] | 3-6,2-6 | |
| Challenger Murcia | 09/27 15:15 | 25 | [257] Flavio Cobolli v Mario Vilella Martinez [171] | 7-5,6-3 | |
| Challenger Quito | 09/16 15:00 | 26 | [169] Mario Vilella Martinez v Gonzalo Lama [417] | 6-3,6-7,3-6 | |
| Challenger Quito | 09/14 16:50 | 25 | Mario Vilella Martinez v Christian Langmo | 6-3,6-7,6-2 | |
| US Open | 08/25 19:40 | 14 | [131] Yuichi Sugita v Mario Vilella Martinez [162] | 3-6,6-3,6-2 | |
| ATP Kitzbuhel | 07/28 18:30 | 26 | [14] Casper Ruud v Mario Vilella Martinez [167] | 7-5,5-7,6-4 | |
| ATP Kitzbuhel | 07/27 10:35 | 25 | Mario Vilella Martinez v Lukas Neumayer | 6-7,7-5,6-4 | |
| ATP Kitzbuhel | 07/25 10:00 | 19 | [130] Jozef Kovalik v Mario Vilella Martinez [158] | 7-5,7-5 | |
| ATP Kitzbuhel | 07/24 13:05 | 26 | [313] Lucas Miedler v Mario Vilella Martinez [158] | 3-6,4-6 | |
| Challenger Tampere | 07/23 12:00 | 27 | [158] Mario Vilella Martinez v Nicolas Kicker [384] | 6-7,0-6 | |
| Challenger Tampere | 07/22 09:00 | 26 | [158] Mario Vilella Martinez v Pedro Cachin [278] | 7-5,6-4 | |
| Challenger Tampere | 07/20 12:40 | 25 | [158] Mario Vilella Martinez v Joao Domingues [238] | 4-6,7-6,7-5 | |
| Challenger Todi | 07/18 18:30 | 29 | [151] Federico Gaio v Mario Vilella Martinez [178] | 6-7,6-1,3-6 | |
| Challenger Todi | 07/17 16:35 | 28 | [409] Matheus P De Almeida v Mario Vilella Martinez [178] | 6-7,6-3,1-6 | |
| Challenger Todi | 07/16 13:00 | 27 | [316] Giulio Zeppieri v Mario Vilella Martinez [178] | 3-6,3-6 | |
| Challenger Todi | 07/15 13:00 | 26 | [368] Francesco Forti v Mario Vilella Martinez [178] | 3-6,1-6 | |
| Challenger Todi | 07/13 15:00 | 25 | [252] Tristan Lamasine v Mario Vilella Martinez [178] | 2-6,6-7 | |
| Challenger Braunschweig | 07/07 11:15 | 26 | [166] Daniel Altmaier v Mario V. Martinez [179] | 6-3,6-2 | |
| Challenger Braunschweig | 07/05 15:20 | 25 | [179] Mario V. Martinez v Rudolf Molleker [311] | 3-6,6-4,6-3 | |
| Wimbledon | 06/22 13:25 | 14 | [418] Andrey Kuznetsov v Mario Vilella Martinez [176] | 6-4,6-7,6-2 | |
| Challenger Nottingham - Qual. | 06/13 12:00 | 14 | [183] Mario Vilella Martinez v Matthew Ebden [230] | 3-6,3-6 |