Tijuana femminile

Beginnings

In December 2016, the then-president of Liga MX, Enrique Bonilla, announced the formation of a new women's professional league, Liga MX Femenil. Each of the 16 clubs in the new league was to be attached to an existing Liga MX side. Tijuana already had a women's side, founded in 2014 by Marbella Ibarra that competed in various US-based leagues, including the Women's Premier Soccer League.

Liga MX Femenil

In February 2017, the club announced through its social media channels that it would be forming a women's side. That May, the 2017 Copa MX Femenil was contested between 12 teams, including Xolos Femenil. Las Perrísimas won their group, which also included Necaxa, Santos, and Rayadas. In the final, Tijuana fell 9–1 to Club Pachuca.

On July 29, 2017, led by technical director Andrea Rodebaugh, the Xolas debuted in Apertura 2017 on the road against Club América, a match they lost 1–0. Tijuana had been drawn into Group 2, along with América, Pachuca, Toluca, Pumas, Monarcas, Cruz Azul, and Veracruz.

The first goal by the Xoloitzcuintles in Liga MX Femenil was scored by Evelyn Fernández in week two of the Apertura tournament.

On July 8, 2021, Club Tijuana signed their first-ever foreign player, American striker Angelina Hix, from the Chilean club Santiago Morning. Hix had played in both the Copa Libertadores and the UEFA Champions League.

Mexican-American forward Renae Cuéllar is the top scorer in club history, with 76 career goals for the Xolas.

Present

Over the last two seasons, Tijuana has established itself as one of the top clubs in the league, having qualified for two consecutive years for the Liguilla. In Clausura 2023, the club recorded a historic 2–0 victory in the first leg of the quarterfinals, at home against Rayadas.