stadio: Armstrong Stadium Round: 1
Home Manager: Robert Prunty Away Manager: Chris Willis
| NCAAF | 2021/11/13 20:00 | Kennesaw State v North Alabama | L | 28-24 |
| NCAAF | 2021/11/06 17:00 | North Alabama v Monmouth | L | 33-45 |
| NCAAF | 2021/10/23 19:00 | Charleston Southern v North Alabama | W | 22-45 |
| NCAAF | 2021/10/16 23:00 | Robert Morris v North Alabama | W | 31-42 |
| NCAAF | 2021/10/09 17:00 | North Alabama v North Carolina A&T | L | 34-38 |
| NCAAF | 2021/10/02 23:00 | Campbell v North Alabama | L | 48-31 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | L | 14-31 |
| NCAAF | 2021/09/18 23:00 | North Alabama v Jacksonville State | L | 24-27 |
| NCAAF | 2021/11/13 18:00 | Hampton v Campbell | W | 28-21 |
| NCAAF | 2021/11/06 17:00 | Gardner Webb v Hampton | W | 21-27 |
| NCAAF | 2021/10/30 16:00 | Hampton v Robert Morris | L | 35-38 |
| NCAAF | 2021/10/23 18:00 | North Carolina A&T v Hampton | W | 9-30 |
| NCAAF | 2021/10/16 22:00 | Hampton v Charleston Southern | L | 5-35 |
| NCAAF | 2021/10/09 18:00 | Kennesaw State v Hampton | L | 34-15 |
| NCAAF | 2021/10/02 18:00 | Norfolk State v Hampton | L | 47-44 |
| NCAAF | 2021/09/18 16:00 | Hampton v Howard | W | 48-32 |