stadio: Roy Stewart Stadium Round: 1
Home Manager: Dean Hood Away Manager: Dewayne Alexander
| NCAAF | 2021/03/14 18:30 | Murray State v Tennessee Tech | L | 36-31 |
| NCAAF | 2019/11/02 18:00 | Tennessee Tech v Murray State | W | 17-7 |
| NCAAF FCS | 2018/11/03 18:30 | Murray State v Tennessee Tech | W | 24-27 |
| NCAAF | 2017/11/11 19:00 | Murray State v Tennessee Tech | L | 31-21 |
| NCAAF | 2021/10/23 18:30 | Tennessee Tech v Lynchburg Dragons | W | 56-13 |
| NCAAF | 2021/10/16 19:00 | Tennessee Tech v Tennessee State | L | 13-20 |
| NCAAF | 2021/10/09 18:00 | Tennessee Tech v North Carolina Central | W | 27-16 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | W | 17-28 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | L | 28-14 |
| NCAAF | 2021/09/18 16:00 | Tennessee Tech v Tennessee | L | 0-56 |
| NCAAF | 2021/09/11 18:30 | Furman v Tennessee Tech | L | 26-0 |
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | L | 14-52 |
| NCAAF | 2021/10/30 22:00 | Murray State v Tennessee State | L | 21-27 |
| NCAAF | 2021/10/23 19:00 | Austin Peay v Murray State | L | 47-6 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | W | 32-31 |
| NCAAF | 2021/10/09 19:00 | Murray State v Tennessee Martin | L | 24-48 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | W | 6-22 |
| NCAAF | 2021/09/18 21:00 | Murray State v Bowling Green | L | 10-27 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | L | 7-42 |
| NCAAF | 2021/09/03 00:00 | Mississippi Valley State v Murray State | W | 0-35 |