[46] Purdue 31-59 Ohio State [16] 2021-11-13 20:30
stadio: Ohio Stadium Round: 1
Home Manager: Ryan Day Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2018/10/20 23:30 | Ohio State v Purdue | W | 20-49 |
| NCAAF | 2012/10/20 12:00 | Ohio State v Purdue | L | 29-22 |
| NCAAF | 2011/11/12 12:00 | Purdue v Ohio State | W | 26-23 |
| NCAAF | 2010/10/23 12:00 | Ohio State v Purdue | L | 49-0 |
| NCAAF | 2009/10/17 12:00 | Purdue v Ohio State | W | 26-18 |
| NCAAF | 2008/10/11 12:00 | Ohio State v Purdue | L | 16-3 |
| NCAAF | 2007/10/06 12:00 | Purdue v Ohio State | L | 7-23 |
| NCAAF | 2004/11/13 12:00 | Purdue v Ohio State | W | 24-17 |
Home History
| NCAAF | 2021/11/06 19:30 | Michigan State v Purdue | W | 29-40 |
| NCAAF | 2021/10/30 19:30 | Purdue v Nebraska | W | 28-23 |
| NCAAF | 2021/10/23 19:00 | Wisconsin v Purdue | L | 30-13 |
| NCAAF | 2021/10/16 19:30 | Purdue v Iowa | W | 24-7 |
| NCAAF | 2021/10/02 16:00 | Minnesota v Purdue | L | 20-13 |
| NCAAF | 2021/09/25 19:30 | Illinois v Purdue | W | 9-13 |
| NCAAF | 2021/09/18 18:30 | Purdue v Notre Dame | L | 13-27 |
| NCAAF | 2021/09/11 19:00 | Purdue v Connecticut | W | 49-0 |
Away History
| NCAAF | 2021/11/06 16:00 | Ohio State v Nebraska | W | 26-17 |
| NCAAF | 2021/10/30 23:30 | Penn State v Ohio State | W | 24-33 |
| NCAAF | 2021/10/23 23:30 | Ohio State v Indiana | W | 54-7 |
| NCAAF | 2021/10/09 16:00 | Maryland v Ohio State | W | 17-66 |
| NCAAF | 2021/10/02 19:30 | Ohio State v Rutgers | W | 52-13 |
| NCAAF | 2021/09/25 23:30 | Akron v Ohio State | W | 7-59 |
| NCAAF | 2021/09/18 19:30 | Tulsa v Ohio State | W | 20-41 |
| NCAAF | 2021/09/11 16:00 | Oregon v Ohio State | L | 35-28 |