[18] Santos Laguna 2-3 Club America [17] 2022-02-13 03:00
stadio: Estadio TSM Corona Round: 5
Arbitro: Luis Enrique Santander Aguirre Home Manager: Pedro Caixinha Away Manager: Santiago Solari
Head to Head
| Messico - Liga MX | 2021/10/20 00:05 | Club America v Santos Laguna | L | 2-1 |
| Amichevoli Europa | 2021/07/05 00:30 | Club America v Santos Laguna | L | 1-0 |
| Messico - Liga MX | 2021/02/01 01:06 | Santos Laguna v Club America | D | 1-1 |
| Messico - Liga MX | 2020/08/14 02:00 | Club America v Santos Laguna | L | 3-1 |
| Messico - Liga MX | 2019/11/03 01:00 | Club America v Santos Laguna | W | 1-2 |
| Messico - Liga MX | 2019/04/28 00:00 | Club America v Santos Laguna | L | 1-0 |
| Amichevoli per club resto del mondo | 2018/12/29 22:30 | Club America v Santos Laguna | D | 1-1 |
| Messico - Liga MX | 2018/11/12 00:00 | Santos Laguna v Club America | D | 1-1 |
Home History
| Messico - Liga MX | 2022/02/07 00:00 | Atlas v Santos Laguna | L | 2-1 |
| Amichevoli Europa | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | L | 2-1 |
| Messico - Liga MX | 2022/01/24 01:00 | Santos Laguna v Necaxa | L | 1-4 |
| Messico - Liga MX | 2022/01/16 18:00 | Toluca v Santos Laguna | L | 3-1 |
| Messico - Liga MX | 2022/01/13 02:06 | Santos Laguna v Tigres UANL | D | 1-1 |
| Messico - Liga MX | 2021/11/29 00:00 | Tigres UANL v Santos Laguna | L | 1-0 |
| Messico - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | W | 2-1 |
| Messico - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | W | 2-0 |
Away History
| Messico - Liga MX | 2022/02/06 01:00 | Club America v Atletico San Luis | L | 2-3 |
| Messico - Liga MX | 2022/01/23 03:00 | Club America v Atlas | L | 0-2 |
| Messico - Liga MX | 2022/01/08 03:00 | Puebla v Club America | D | 1-1 |
| Messico - Liga MX | 2021/11/28 01:00 | Club America v Unam Pumas | L | 1-3 |
| Messico - Liga MX | 2021/11/25 01:00 | Unam Pumas v Club America | D | 0-0 |
| Messico - Liga MX | 2021/11/07 01:00 | Club America v Monterrey | D | 0-0 |
| Messico - Liga MX | 2021/10/31 23:05 | Cruz Azul v Club America | L | 2-1 |
| CONCACAF - Coppa dei Campioni | 2021/10/29 02:00 | Monterrey v Club America | L | 1-0 |