stadio: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Chris Wilkerson
| NCAAF | 2022/11/12 20:00 | SE Missouri St v Eastern Illinois | L | 31-7 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | L | 7-47 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | L | 26-12 |
| NCAAF FCS | 2018/11/17 19:00 | Eastern Illinois v SE Missouri St | L | 32-38 |
| NCAAF | 2017/09/23 23:00 | Eastern Illinois v SE Missouri St | W | 19-16 |
| NCAAF | 2023/10/07 19:00 | Tennessee Martin v Eastern Illinois | L | 28-27 |
| NCAAF | 2023/09/30 23:00 | Eastern Illinois v Northwestern State | W | 19-10 |
| NCAAF | 2023/09/23 19:00 | McNeese State v Eastern Illinois | W | 28-31 |
| NCAAF | 2023/09/16 19:00 | Illinois State v Eastern Illinois | W | 13-14 |
| NCAAF | 2023/09/09 18:00 | Eastern Illinois v Bowling Green | L | 15-38 |
| NCAAF | 2023/08/31 22:00 | Eastern Illinois v Indiana State | W | 27-0 |
| NCAAF | 2022/11/19 20:00 | Eastern Illinois v Tennessee Martin | L | 31-34 |
| NCAAF | 2022/11/12 20:00 | SE Missouri St v Eastern Illinois | L | 31-7 |
| NCAAF | 2023/10/07 21:00 | SE Missouri St v Central Arkansas | L | 33-38 |
| NCAAF | 2023/09/23 22:00 | SE Missouri St v Eastern Kentucky | L | 38-41 |
| NCAAF | 2023/09/16 23:00 | SO Illinois v SE Missouri St | L | 26-25 |
| NCAAF | 2023/09/09 23:00 | Lindenwood v SE Missouri St | W | 7-45 |
| NCAAF | 2023/09/02 23:00 | SE Missouri St v Kansas State | L | 0-45 |
| NCAAF | 2022/11/27 03:00 | SE Missouri St v Montana | L | 24-34 |
| NCAAF | 2022/11/19 19:00 | Murray State v SE Missouri St | W | 22-52 |
| NCAAF | 2022/11/12 20:00 | SE Missouri St v Eastern Illinois | W | 31-7 |