Head to Head
| Preseason NFL | 2017/08/31 23:00 | BUF Bills v DET Lions | L | 27-17 |
| Preseason NFL | 2016/09/01 23:30 | DET Lions v BUF Bills | W | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | L | 14-17 |
Home History
| NFL | 2018/12/09 21:25 | DET Lions v ARZ Cardinals | W | 17-3 |
| NFL | 2018/12/02 18:00 | LA Rams v DET Lions | L | 30-16 |
| NFL | 2018/11/22 17:30 | CHI Bears v DET Lions | L | 23-16 |
| NFL | 2018/11/18 18:00 | CAR Panthers v DET Lions | W | 19-20 |
| NFL | 2018/11/11 18:00 | DET Lions v CHI Bears | L | 22-34 |
| NFL | 2018/11/04 18:00 | DET Lions v MIN Vikings | L | 9-24 |
| NFL | 2018/10/28 17:00 | SEA Seahawks v DET Lions | L | 28-14 |
| NFL | 2018/10/21 17:00 | DET Lions v MIA Dolphins | W | 32-21 |
Away History
| NFL | 2018/12/09 18:00 | NY Jets v BUF Bills | L | 27-23 |
| NFL | 2018/12/02 18:00 | BUF Bills v MIA Dolphins | L | 17-21 |
| NFL | 2018/11/25 18:00 | JAX Jaguars v BUF Bills | W | 21-24 |
| NFL | 2018/11/11 18:00 | BUF Bills v NY Jets | W | 41-10 |
| NFL | 2018/11/04 18:00 | CHI Bears v BUF Bills | L | 41-9 |
| NFL | 2018/10/30 00:15 | NE Patriots v BUF Bills | L | 25-6 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | L | 5-37 |
| NFL | 2018/10/14 17:00 | BUF Bills v HOU Texans | L | 13-20 |