| NCAAF | 11/18 18:00 | 1 | Charleston Southern v Gardner Webb | L | 10-34 | |
| NCAAF | 11/11 17:00 | 1 | Charleston Southern v Robert Morris | L | 12-14 | |
| NCAAF | 11/04 20:00 | 1 | Tennessee State v Charleston Southern | W | 21-35 | |
| NCAAF | 10/28 20:00 | 1 | Bryant v Charleston Southern | L | 47-24 | |
| NCAAF | 10/21 19:00 | 1 | Charleston Southern v Tennessee Martin | L | 0-17 | |
| NCAAF | 10/14 20:00 | 1 | Lindenwood v Charleston Southern | W | 10-24 | |
| NCAAF | 09/30 22:00 | 1 | Kennesaw State v Charleston Southern | W | 10-13 | |
| NCAAF | 09/23 18:30 | 1 | Charleston Southern v Western Carolina | L | 21-77 | |
| NCAAF | 09/16 20:00 | 1 | William & Mary v Charleston Southern | L | 15-7 | |
| NCAAF | 09/09 18:15 | 1 |
[39] Charleston Southern
v
Clemson
[115] 
|
L | 17-66 | |
| NCAAF | 08/31 22:00 | 1 | Charleston Southern v North Greenville Crusaders | W | 13-10 | |
| NCAAF | 11/12 17:00 | 1 | Charleston Southern v North Carolina A&T | L | 10-20 | |
| NCAAF | 11/05 16:00 | 1 | Robert Morris v Charleston Southern | W | 21-34 | |
| NCAAF | 10/29 17:00 | 1 | Charleston Southern v Kennesaw State | L | 20-30 | |
| NCAAF | 10/22 22:00 | 1 | Gardner Webb v Charleston Southern | L | 28-14 | |
| NCAAF | 10/15 20:00 | 1 | Charleston Southern v Bryant | W | 24-23 | |
| NCAAF | 10/08 20:00 | 1 | Charleston Southern v Campbell | L | 28-34 | |
| NCAAF | 09/24 16:00 | 1 | Furman v Charleston Southern | L | 24-19 | |
| NCAAF | 09/17 22:00 | 1 | Charleston Southern v Eastern Kentucky | L | 17-40 | |
| NCAAF | 09/10 16:30 | 1 |
[75] Charleston Southern
v
NC State
[3] 
|
L | 3-55 | |
| NCAAF | 09/03 16:00 | 1 | Western Carolina v Charleston Southern | L | 52-38 | |
| NCAAF | 11/20 17:00 | 1 |
[72] Charleston Southern
v
Georgia
[1] 
|
L | 7-56 | |
| NCAAF | 11/13 18:30 | 1 | Charleston Southern v Gardner Webb | W | 32-24 | |
| NCAAF | 11/06 17:00 | 1 | North Carolina A&T v Charleston Southern | L | 21-18 | |
| NCAAF | 10/30 17:00 | 1 | [59] Campbell v Charleston Southern [92] | W | 14-27 | |
| NCAAF | 10/23 19:00 | 1 | Charleston Southern v North Alabama | L | 22-45 | |
| NCAAF | 10/16 22:00 | 1 | Hampton v Charleston Southern | W | 5-35 | |
| NCAAF | 10/09 19:00 | 1 | Charleston Southern v Robert Morris | L | 24-31 | |
| NCAAF | 09/25 22:00 | 1 |
[57] Charleston Southern
v
East Carolina
[102] 
|
L | 28-31 | |
| NCAAF | 09/18 22:00 | 1 | Monmouth v Charleston Southern | L | 41-14 |