[5] BOS Bruins 5-1 BUF Sabres [6] 2021-11-25 00:00
stadio: KeyBank Center
Home Manager: Don Granato Away Manager: Bruce Cassidy
Head to Head
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | W | 4-1 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | W | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | W | 2-5 |
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | L | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | W | 5-1 |
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | W | 2-0 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/27 17:00 | BUF Sabres v BOS Bruins | W | 2-3 |
Home History
| NHL | 2021/11/22 00:00 | CAL Flames v BOS Bruins | L | 4-0 |
| NHL | 2021/11/21 00:00 | BOS Bruins v PHI Flyers | W | 5-2 |
| NHL | 2021/11/15 00:00 | MON Canadiens v BOS Bruins | W | 2-5 |
| NHL | 2021/11/13 18:00 | BOS Bruins v NJ Devils | W | 5-2 |
| NHL | 2021/11/12 00:00 | EDM Oilers v BOS Bruins | L | 5-3 |
| NHL | 2021/11/10 00:00 | OTT Senators v BOS Bruins | W | 2-3 |
| NHL | 2021/11/06 23:00 | BOS Bruins v TOR Maple Leafs | L | 2-5 |
| NHL | 2021/11/04 23:00 | DET Red Wings v BOS Bruins | W | 1-5 |
Away History
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2021/11/09 00:00 | BUF Sabres v WAS Capitals | L | 3-5 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |