| Challenger Nottingham | 06/08 10:00 | 25 | [139] Brandon Nakashima v Mario Vilella Martinez [183] | 6-3,6-2 | |
| Open di Francia | 05/30 11:00 | 23 | [182] Mario Vilella Martinez v Roberto Bautista-Agut [11] | 4-6,4-6,2-6 | |
| Open di Francia | 05/28 08:30 | 19 | [182] Mario Vilella Martinez v Peter Gojowczyk [134] | 4-6,6-3,6-2 | |
| Open di Francia | 05/26 13:50 | 15 | [182] Mario Vilella Martinez v Filip Horansky [186] | 6-2,6-3 | |
| Open di Francia | 05/25 13:55 | 14 | [110] Dennis Novak v Mario Vilella Martinez [182] | 6-1,2-6,2-6 | |
| Challenger Praga | 05/04 14:10 | 25 | [176] Kacper Zuk v Mario Vilella Martinez [178] | 7-6,2-6,7-5 | |
| ATP Marbella | 04/07 16:10 | 26 | [15] Pablo Carreno-Busta v Mario Vilella Martinez [188] | 7-6,6-3 | |
| ATP Marbella | 04/06 12:00 | 25 | [146] Bernabe Zapata Miralles v Mario Vilella Martinez [188] | 2-6,3-6 | |
| ATP Marbella | 04/05 11:35 | 19 | [188] Mario Vilella Martinez v Carlos Gomez-Herrera [350] | 6-3,3-6,6-3 | |
| ATP Marbella | 04/04 13:50 | 14 | [131] Antoine Hoang v Mario Vilella Martinez [196] | 2-6,4-6 | |
| Challenger Marbella | 04/03 12:35 | 28 | [99] Jaume Munar v Mario Vilella Martinez [196] | 7-6,7-5 | |
| Challenger Marbella | 04/02 12:00 | 27 | [196] Mario Vilella Martinez v Nikola Milojevic [148] | 6-3,6-4 | |
| Challenger Marbella | 04/01 10:00 | 26 | [126] Damir Dzumhur v Mario Vilella Martinez [196] | 3-6,4-6 | |
| Challenger Marbella | 03/30 09:00 | 25 | [196] Mario Vilella Martinez v Lorenzo Giustino [164] | 7-6,6-0 | |
| ATP Miami | 03/23 14:00 | 19 | [196] Mario Vilella Martinez v Thanasi Kokkinakis [243] | 5-7,1-6 | |
| ATP Miami | 03/22 14:00 | 14 | [133] Cedrik-Marcel Stebe v Mario Vilella Martinez [196] | 6-7,3-6 | |
| ATP Santiago | 03/07 18:40 | 15 | [236] Felipe M R Alves v Mario Vilella Martinez [196] | 3-6,7-6,7-6 | |
| ATP Santiago | 03/06 19:40 | 14 | [291] Lukas Klein v Mario Vilella Martinez [196] | 4-6,2-6 | |
| ATP Buenos Aires | 02/28 21:00 | 15 | [148] Sumit Nagal v Mario Vilella Martinez [193] | 6-4,6-2 | |
| ATP Buenos Aires | 02/27 13:00 | 14 | [193] Mario Vilella Martinez v Marcelo T B Vera [265] | 6-4,7-5 | |
| ATP Cordoba | 02/20 15:20 | 14 | [390] Agustin Velotti v Mario Vilella Martinez [181] | 6-3,6-4 | |
| Australian Open | 02/09 06:15 | 23 | [199] Tomas Machac v Mario Vilella Martinez [181] | Retired | |
| ATP Great Ocean Road Open | 02/04 23:30 | 26 | [52] Jordan Thompson v Mario Vilella Martinez [188] | 6-4,6-4 | |
| ATP Great Ocean Road Open | 02/03 08:05 | 25 | [188] Mario Vilella Martinez v Nikoloz Basilashvili [39] | 7-5,6-3 | |
| ATP Great Ocean Road Open | 02/02 06:05 | 24 | [101] Yannick Hanfmann v Mario Vilella Martinez [188] | 6-7,4-6 | |
| Australian Open | 01/13 07:30 | 19 | [247] Tung-Lin Wu v Mario Vilella Martinez [186] | 6-4,5-7,4-6 | |
| Australian Open | 01/12 07:30 | 15 | Mario Vilella Martinez v Francisco Cerundolo | Walkover | |
| Australian Open | 01/10 10:40 | 60 | [162] Alessandro Giannessi v Mario Vilella Martinez [186] | 1-6,3-6 | |
| Challenger Lima | 11/24 16:45 | 25 | [91] Federico Coria v Mario Vilella Martinez [190] | 6-2,6-4 | |
| Challenger Guayaquil | 11/17 15:00 | 25 | [349] Jesper De Jong v Mario Vilella Martinez [187] | 5-7,6-3,7-5 |